1- Genotoxins include chemical substances and ……………
(a) Agents
(b) Fertilizers
(c) Pesticides
(d) Radiation
2- …………………… are birth defect causing agents.
(a) Teratogens
(b) Cancer
(c) DNA
(d) None
3- ………….. are mutation causing agents.
(a) Carcinogens
(b) Mutagens
(c) Teratogens
(d) None
4- All mutagens are genotoxic however all genotoxins are not …………
(a) Carcinogenic
(b) Harmful
(c) Mutagenic
(d) None
5- The damage of genetic material of somatic cells may lead to ………… in eukaryotic organisms.
(a) Malignancy
(b) Harmfull
(c) Inflammation
(d) All
6- The damage of …………. May lead to heritable diseases.
(a) Liver
(b) Somatic cells
(c) Heart
(d) Germ cells
7- Electrophilic species can form ………… to DNA.
(a) Covalent adducts
(b) Inflammation
(c) Bonding
(d) None
8- Topoisomerase act as ……….. that damage DNA.
(a) Activators
(b) Inhibitors
(c) Neutralizars
(d) None
9- ………….. are known to be genotoxic in nature.
(a) Oxygen
(b) Carbon
(c) Hydrogen
(d) Reactive oxygen species
10- The genotoxins act at specific location or ……… to damage DNA.
(a) Base
(b) Nucleotide
(c) Phosphorus group
(d) None
11- DNA lesions are formed when DNA interacts with …………
(a) Hydrogen
(b) Carbon
(c) Chromium
(d) Lead
12- When carcinogenic exposure takes place its ………… phase cause cancer.
(a) Activation
(b) Inactivation
(c) Both a and b
(d) None
13- …………….. inhibit the mutagens.
(a) Mutagens
(b) Carcinogens
(c) Antimutagens
(d) None
14- Demutagens ………… the mutagens.
(a) Form
(b) Destroy
(c) Pack
(d) None
15- ………….. mutagens decreases the effect of mutagens
(a) Carcinogens
(b) Anti-mutagens
(c) Teratogens
(d) All
16- …………… in which factors on mutagens are inactivated .
(a) Desmutagens
(b) Antimutagins
(c) Both a and b
(d) None
17- Ultra violet or ionizing radiation ………….. DNA.
(a) Form
(b) Stretch
(c) Damage
(d) All
18- Aconite destroy the ……….
(a) LIVER
(b) Lungs
(c) RNA
(d) DNA
19- when carcinogenic agents are in ………… phase it doesnot damage body.
(a) Inactivation
(b) Activation
(c) Neutral
(d) None
20- Reactive ………… are generated by decomposition of lipid peroxyl radicals.
(a) Peroxides
(b) Ketones
(c) Aldehydes
(d) Hydroxyls
21- 4- hydroxynonenal can stimulate the …………
(a) Heart
(b) Cell proliferation
(c) Oxides
(d) All
22- 4- hydroxynonenal is involved in many of oxidative stress related disease ………….
(a) Fibrosis
(b) Anemia
(c) Paralysis
(d) None
23- In ………….repair system base is damage.
(a) Direct repair
(b) Base excision
(c) Mismatch repair
(d) All
24- Nucleotide excision repair damage the ………..
(a) Base
(b) DNA
(c) RNA
(d) Nucleotide
25- Genotoxicity used in prediction of toxins and damage in ………
(a) Heart
(b) DNA and RNA
(c) BOTh a and b
(d) None
26- Genotoxicity destroy the ………
(a) Cell
(b) Mitochondria
(c) Gene
(d) None
27- …………… are cancer causing agents.
(a) Carcinogens
(b) Mutagens
(c) Teratogens
(d) All
28- Genotoxic risk may cause genetic diseases which lead to ………..
(a) Cancer
(b) Sterility
(c) Sickle cell anemia
(d) All
29- ……………………. Are genotoxic in nature.
(a) CARCINOGENS
(b) UV rays
(c) Plants
(d) Reactive oxygen species
30- Genotxins are mutagens that destroy…………
(a) Nose
(b) Genes
(c) Liver
(d) heart
Answer Key:
1- C
2- D
3- A
4- B
5- C
6- A
7- D
8- A
9- B
10- D
11- A
12- C
13- A
14- C
15- B
16- B
17- A
18- C
19- D
20- A
21- C
22- B
23- A
24- B
25- D
26- B
27- C
28- A
29- C
30- D
