Cytochrome p450

1.Who detected a CO binding pigment in liver microsomes……

  1. Garfinkel
  2. Klingenbeg
  3. Both a and b

2. P450 cam structure was solved in …….

  1. 1987
  2. 1948
  3. 1957

3. The CO binding pigment in  liver microsome had an absorption maximum at …..

  1. 430nm
  2. 490nm
  3. 450nm

4. The cytochrome P450 superfamily is large and diverse group of ……

  1. Vitamins
  2. Carbohydrates
  3. Enzymes

5. Name the most common reaction that is catalyzed by CYP450 ……

  1. Monoxygenase reaction
  2. Dioxygenase reaction
  3. Trioxygenase reaction

6. The P450 superfamily is believed to have originated from an ancestral gene that existed over …..

  1. 4 billion years ago
  2. 5 billion years ago
  3. 3 billion years ago

7. Where CYP450 found in our body …..

  1. Mitochondria
  2. Endoplasmic reticulum
  3. Both a and b

8. Which statement is false about CYP450…..

  1. Its not detoxify xenobiotics sources of toxicity
  2. To assist in the synthesis of vitamin D
  3. To function within phase 1 Liver detoxification

9. Which one is the example of inhibitor that is added to substrate…..

  1. Nortriptyline
  2. Paroxetine
  3. Carbamazepine

10. Which one is  not the example of substrate that is added to inducer ….

  1. Cimetidine
  2. Paroxetine
  3. All of the above

11. The process of drug –drug interaction included—— patterns.

  1. 5
  2. 6
  3. 7

12. Cimetidine is discontinued in the presence of nortriptyline leading to a decrease in —– blood level.

  1. Paroxetine
  2. Nortriptyline
  3. None of them

13. Is P450 induction limited to drugs?

  1. Yes
  2. No
  3. None of them

14. In humans —-no. of Cyp450 isomers are identified.

  1. 50
  2. 60
  3. 110

15. CYP450  belong to the superfamily of proteins containing a heme group as a ….

  1. Cofactor
  2. Co enzymes
  3. None of them

16. The inactivation of CYP19A is done by ….

  1. Exemestane
  2. Abiraterone
  3. Both a and b

17. The inactivation of CYP19A by exemestone and of CYP17A by abiraterone are used to treat patients of …..

  1. Cancer patients
  2. Heart patients
  3. None of them

18.Genetic polymorphism of CYP genes can cause …..

  1. Drug interaction
  2. Genetic disease
  3. All of the above

19. The MBI of human CYP plays an important role in therapeutic efficacy of ….

  1. Drugs
  2. Metal
  3. All of the above

20. P450 enzymes CYP19A and CYP17A play an important role in the progression of ….

  1. Breast cancer
  2. Prostate cancer
  3. Both a and b