1.Who detected a CO binding pigment in liver microsomes……
- Garfinkel
- Klingenbeg
- Both a and b
2. P450 cam structure was solved in …….
- 1987
- 1948
- 1957
3. The CO binding pigment in liver microsome had an absorption maximum at …..
- 430nm
- 490nm
- 450nm
4. The cytochrome P450 superfamily is large and diverse group of ……
- Vitamins
- Carbohydrates
- Enzymes
5. Name the most common reaction that is catalyzed by CYP450 ……
- Monoxygenase reaction
- Dioxygenase reaction
- Trioxygenase reaction
6. The P450 superfamily is believed to have originated from an ancestral gene that existed over …..
- 4 billion years ago
- 5 billion years ago
- 3 billion years ago
7. Where CYP450 found in our body …..
- Mitochondria
- Endoplasmic reticulum
- Both a and b
8. Which statement is false about CYP450…..
- Its not detoxify xenobiotics sources of toxicity
- To assist in the synthesis of vitamin D
- To function within phase 1 Liver detoxification
9. Which one is the example of inhibitor that is added to substrate…..
- Nortriptyline
- Paroxetine
- Carbamazepine
10. Which one is not the example of substrate that is added to inducer ….
- Cimetidine
- Paroxetine
- All of the above
11. The process of drug –drug interaction included—— patterns.
- 5
- 6
- 7
12. Cimetidine is discontinued in the presence of nortriptyline leading to a decrease in —– blood level.
- Paroxetine
- Nortriptyline
- None of them
13. Is P450 induction limited to drugs?
- Yes
- No
- None of them
14. In humans —-no. of Cyp450 isomers are identified.
- 50
- 60
- 110
15. CYP450 belong to the superfamily of proteins containing a heme group as a ….
- Cofactor
- Co enzymes
- None of them
16. The inactivation of CYP19A is done by ….
- Exemestane
- Abiraterone
- Both a and b
17. The inactivation of CYP19A by exemestone and of CYP17A by abiraterone are used to treat patients of …..
- Cancer patients
- Heart patients
- None of them
18.Genetic polymorphism of CYP genes can cause …..
- Drug interaction
- Genetic disease
- All of the above
19. The MBI of human CYP plays an important role in therapeutic efficacy of ….
- Drugs
- Metal
- All of the above
20. P450 enzymes CYP19A and CYP17A play an important role in the progression of ….
- Breast cancer
- Prostate cancer
- Both a and b